Viagra - Sildenafil citrate, Sildenafil
Explanation of Viagra, External Links
Sildenafil
citrate, sold as names Viagra Revatio, and Caverta, is a drug used to treat male
erectile dysfunction (impotence) and pulmonary arterial hypertension, developed
by the health pharmaceutical company Pfizer. Viagra pills, are intended to treat
impotence, and are blue with the words "Pfizer" on one side and "VGR
xx" Its primary competitor on the market is tadalafil
Sildenafil was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections.
The drug became a major reference in modern culture. The name "Viagra", like many drug names, is a marketing invention. Mnay claim it is due to the anem Niagra falls.
Even though Viagra is only available
by prescription from a doctor, it was advertised directly to consumers on TV (famously
being endorsed by Bob Dole). Pele advertised the product for a while too.
Side
effects include
In men for whom sexual intercourse is inadvisable due to cardiovascular
risk factors
Severe hepatic impairment, decreased liver function
Severe
impairment in renal function
Hypotension low blood pressure
Recent stroke
or heart attack
Hereditary degenerative retinal disorders ,including genetic
disorders of retinal phosphodiesterases
Amongst sildenafil's serious adverse
effects are: priapism, severe hypotension, myocardial infarction, ventricular
arrhythmias, sudden death, stroke and increased intraocular pressure.
Common side effects include sneezing, headache, flushing, dyspepsia, prolonged erections, palpitations and photophobia. Visual changes including blurring of vision and a curious bluish tinge.
Care must be exercised by patients taking Protease inhibitors for treatment of HIV. Protease inhibitors inhibit the metabolism of sildenafil, multiplying the plasma levels of sildenafil, increasing the incidence and severity of side-effects. Doctors recommended that patients using protease inhibitors limit their use of sildenafil. Please look up official papers to see the limits.
http://www.fda.gov/cder/consumerinfo/viagra/
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